Regulation of ErbB2 receptor status by the proteasomal DUB POH1.
Understanding the factors, which control ErbB2 and EGF receptor (EGFR) status in cells is likely to inform future therapeutic approaches directed at these potent oncogenes.ErbB2 is resistant to stimulus-induced degradation and high levels of over-expression can inhibit EGF receptor down-regulation.We now show that for HeLa cells expressing similar